• The causes and consequences of Alzheimer’s disease: phenome-wide evidence from Mendelian randomization 

      Korologou-Linden, Roxanna; Bhatta, Laxmi; Brumpton, Ben Michael; Howe, Laura D.; Millard, Louise A. C.; Kolaric, Katarina; Ben-Shlomo, Yoav; Williams, Dylan M.; Smith, George Davey; Anderson, Emma L.; Stergiakouli, Evie; Davies, Neil Martin (Peer reviewed; Journal article, 2022)
      Alzheimer’s disease (AD) has no proven causal and modifiable risk factors, or effective interventions. We report a phenome-wide association study (PheWAS) of genetic liability for AD in 334,968 participants of the UK Biobank ...
    • Is disrupted sleep a risk factor for Alzheimer's disease? Evidence from a two-sample Mendelian randomization analysis 

      Anderson, Emma L.; Richmond, Rebecca C.; Jones, Samuel E.; Hemani, Gibran; Wade, Kaitlin H; Dashti, Hassan S.; Lane, Jaqueline; Wang, Heming; Saxena, Richa; Brumpton, Ben Michael; Korologou-Linden, Roxanna; Nielsen, Jonas Bille; Åsvold, Bjørn Olav; Abecasis, Goncalo; Coulthard, Elizabeth; Kyle, Simon D.; Beaumont, Robin N.; Tyrell, Jessica; Frayling, Timothy M; Munafo, Marcus R; Wood, Andrew R; Ben-Shlomo, Yoav; Howe, Laura D; Lawlor, Deborah A.; Weedon, Michael N; Smith, George Davey (Peer reviewed; Journal article, 2020)
      Background It is established that Alzheimer’s disease (AD) patients experience sleep disruption. However, it remains unknown whether disruption in the quantity, quality or timing of sleep is a risk factor for the onset ...